I've done two playthroughs of Fallout New Vegas. As far as the game is concerned, the gameplay is vanilla but some mods are used, mainly for improving graphics and removing annoyances. They are:
Stability/core mods
- 4GB Fallout New Vegas
Mission Mojave Ultimate Edition- Yukichigai Unofficial Patch
- New Vegas Script Extender
- New Vegas Anti-Crash
- New Vegas Stutter Remover
UI mods
- CASM
- MTUI
- (I've also tweaked Data/Menus/container_menu.xml to remap "Take All" to Q, to stop me doing it accidentally)
Aesthetic mods
- NMC Texture Pack (highest quality)
- Interior Lighting Overhaul (disabled for Honest Hearts)
Improved Faces v1- Fallout Character Overhaul
- Essential Visual Enhancements
- Fellout
- Holodisk Retexture
- Mikoto Beauty Pack Plus
- Caravan Shotgun Retextured
- Hunting Shotgun Retextured
- PipBoy 3000 HD Retexture
- Riot Shotgun Retex
- Soulful Eyes NV
Other mods
- New Vegas Uncut - Freeside Open
- The Strip Open
A Better Veronica- NV Novac Apartment
- Follower Home Marker
Christmas Special Mods
- Companion Dress Up
- Frozen World
- Placeable Christmas Trees
- Riven's Holiday Style Sleepwear
- Santa's Lil Helper (requires The Warden's Outfit for Type 3 or 6)
- Unlimited Companions
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